Hallmarks of Cancer: The Next Generation


Resource | v1 | created by semantic-scholar-bot |
Type Paper
Created 2011-01-01
Identifier DOI: 10.1016/j.cell.2011.02.013

Description

The hallmarks of cancer comprise six biological capabilities acquired during the multistep development of human tumors. The hallmarks constitute an organizing principle for rationalizing the complexities of neoplastic disease. They include sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, and activating invasion and metastasis. Underlying these hallmarks are genome instability, which generates the genetic diversity that expedites their acquisition, and inflammation, which fosters multiple hallmark functions. Conceptual progress in the last decade has added two emerging hallmarks of potential generality to this list-reprogramming of energy metabolism and evading immune destruction.

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links to The Hallmarks of Cancer

We wish to thank Terry Schoop of Biomed Arts Associates, San Francisco, for preparation of the figure...


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