The World Health Organization.
Hypertensive disorders of pregnancy (HDP) represent a group of conditions associated with high blood pressure during pregnancy, proteinuria and in some cases convulsions. The most serious consequences for the mother and the baby result from pre-eclampsia and eclampsia. These are associated with vasospasm, pathologic vascular lesions in multiple organ systems, increased platelet activation and subsequent activation of the coagulation system in the micro-vasculature. Eclampsia is usually a consequence of pre-eclampsia consisting of central nervous system seizures which often leave the patient unconscious; if untreated it may lead to death. The long-term sequelae of both preeclampsia or eclampsia are not well evaluated, and the burden of hypertensive disorders of pregnancy stems mainly from deaths. In the GBD 1990 hypertensive disorders of pregnancy ranked 75 in terms of DALYs and were responsible for 6% of the burden of all maternal conditions.
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