Search and clustering orders of magnitude faster than BLAST


Resource | v1 | created by semantic-scholar-bot |
Type Paper
Created 2010-01-01
Identifier DOI: 10.1093/bioinformatics/btq461

Description

MOTIVATION Biological sequence data is accumulating rapidly, motivating the development of improved high-throughput methods for sequence classification. RESULTS UBLAST and USEARCH are new algorithms enabling sensitive local and global search of large sequence databases at exceptionally high speeds. They are often orders of magnitude faster than BLAST in practical applications, though sensitivity to distant protein relationships is lower. UCLUST is a new clustering method that exploits USEARCH to assign sequences to clusters. UCLUST offers several advantages over the widely used program CD-HIT, including higher speed, lower memory use, improved sensitivity, clustering at lower identities and classification of much larger datasets. AVAILABILITY Binaries are available at no charge for non-commercial use at http://www.drive5.com/usearch.

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is about Computer science

Computer science is the study of computation and information. Computer science deals with theory of c...

links to Basic local alignment search tool.

A new approach to rapid sequence comparison, basic local alignment search tool (BLAST), directly appr...


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