A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences


Resource | v1 | created by semantic-scholar-bot |
Type Paper
Created 2005-01-01
Identifier DOI: 10.1007/BF01731581

Description

SummarySome simple formulae were obtained which enable us to estimate evolutionary distances in terms of the number of nucleotide substitutions (and, also, the evolutionary rates when the divergence times are known). In comparing a pair of nucleotide sequences, we distinguish two types of differences; if homologous sites are occupied by different nucleotide bases but both are purines or both pyrimidines, the difference is called type I (or “transition” type), while, if one of the two is a purine and the other is a pyrimidine, the difference is called type II (or “transversion” type). Letting P and Q be respectively the fractions of nucleotide sites showing type I and type II differences between two sequences compared, then the evolutionary distance per site is K = — (1/2) ln {(1 — 2P — Q) }. The evolutionary rate per year is then given by k = K/(2T), where T is the time since the divergence of the two sequences.

Relations

relates to MODELTEST: testing the model of DNA substitution

SUMMARY The program MODELTEST uses log likelihood scores to establish the model of DNA evolution that...


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